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This Is Not Your Father's E. Coli

The E. coli that killed dozens and infected thousands of people in Germany last month has a "highly unusual" combination of traits that made it particularly deadly, reports The New York Times' Gina Kolata. Researchers say that one trait was the toxin Shiga — which causes severe illness and kidney failure in some patients — and the other is the bacteria's ability to stack itself in a brick-like pattern on the intestinal wall, possibly to more efficiently pump toxins into the body, Kolata says. "The thought is that the bacteria started out being able to aggregate with the brick pattern and then were infected with a bacterial virus that gave them the Shiga toxin," she adds. According to a new paper published in Lancet Infectious Diseases by researchers at the University of Münster, the two traits combined made the bacteria more virulent than most other strains. The strain is so rate that patients had no immunity against it, the researchers tell Kolata.

The Scan

Harvard Team Report One-Time Base Editing Treatment for Motor Neuron Disease in Mice

A base-editing approach restored SMN levels and improved motor function in a mouse model of spinal muscular atrophy, a new Science paper reports.

International Team Examines History of North American Horses

Genetic and other analyses presented in Science find that horses spread to the northern Rockies and Great Plains by the first half of the 17th century.

New Study Examines Genetic Dominance Within UK Biobank

Researchers analyze instances of genetic dominance within UK Biobank data, as they report in Science.

Cell Signaling Pathway Identified as Metastasis Suppressor

A new study in Nature homes in on the STING pathway as a suppressor of metastasis in a mouse model of lung cancer.