Oftentimes medical practice recommendations are undergirded by expert opinion rather than by multiple randomized control trials and can't quite answer the questions patients and their families have about what treatment is best for them, write Francis Collins, the director of the US National Institutes of Health, Kathy Hudson, the deputy director for science, outreach, and policy at NIH, and their colleagues in a commentary appearing in the Journal of the American Medical Informatics Asso

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