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Not Wanted

A Stanford University study suggests that, like organ transplants, human embryonic stem cells may come with a high probability of rejection. Joseph Wu and his colleagues injected hESCs into mice with compromised immune systems and into normal mice. The mice with compromised immune systems did well while the others died within 10 days. "[This result is] not a disappointment, it's more of a reality check," Wu says at sciam.com. "I think there's some promise [to hESCs], but you don't want to be foolish and say these cells are going to cure things in the next five years."

The Scan

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.

DNA Storage Method Taps Into Gene Editing Technology

With a dual-plasmid system informed by gene editing, researchers re-wrote DNA sequences in E. coli to store Charles Dickens prose over hundreds of generations, as they recount in Science Advances.

Researchers Model Microbiome Dynamics in Effort to Understand Chronic Human Conditions

Investigators demonstrate in PLOS Computational Biology a computational method for following microbiome dynamics in the absence of longitudinally collected samples.

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.