Not So Useful?

An study in the Journal of the American Medical Association found that there was no significant association between a genetic risk score — based on 101 SNPs — and incidence of cardiovascular disease in Caucasian women. Brigham and Women's Hospital's Nina Paynter and her colleagues followed 19,313 participants in the Women's Genome Health Study for a median of 12.3 years and determined the participants' genetic risk scores based on genome-wide association study results. "After adjustment for traditional factors, the genetic risk score did not improve discrimination or reclassification," the authors write, adding that "self-reported family history remained significantly associated with cardiovascular disease in multivariable models." Andrea Anderson at our sister publication GenomeWeb Daily News has more.