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Not So Useful?

An study in the Journal of the American Medical Association found that there was no significant association between a genetic risk score — based on 101 SNPs — and incidence of cardiovascular disease in Caucasian women. Brigham and Women's Hospital's Nina Paynter and her colleagues followed 19,313 participants in the Women's Genome Health Study for a median of 12.3 years and determined the participants' genetic risk scores based on genome-wide association study results. "After adjustment for traditional factors, the genetic risk score did not improve discrimination or reclassification," the authors write, adding that "self-reported family history remained significantly associated with cardiovascular disease in multivariable models." Andrea Anderson at our sister publication GenomeWeb Daily News has more.

The Scan

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.

Team Presents Cattle Genotype-Tissue Expression Atlas

Using RNA sequences representing thousands of cattle samples, researchers looked at relationships between cattle genotype and tissue expression in Nature Genetics.

Researchers Map Recombination in Khoe-San Population

With whole-genome sequences for dozens of individuals from the Nama population, researchers saw in Genome Biology fine-scale recombination patterns that clustered outside of other populations.

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.