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Derek Lowe is used to sketching out compounds that don't yet exist, which he shares in this post at In the Pipeline. But just because there are no literature references doesn't mean a compound is not commercially available for research purposes. He says you "don't have to go that crazy to leave the paved roads behind," as there are many structures that haven't been explored yet.

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Stephen Hahn, the nominee to lead the US Food and Drug Administration, underwent a Senate confirmation hearing yesterday, the Washington Post reports.

The US Food and Drug Administration has approved an RNA interference drug to treat acute hepatic porphyria.

Gizmodo looks over the past decade of consumer DNA testing to find the field to be lacking.

In Nature this week: native RNA sequencing and analysis of a human poly(A) transcriptome, nanopore sequencing-based method to analyze short tandem repeat expansions, and more.