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Derek Lowe is used to sketching out compounds that don't yet exist, which he shares in this post at In the Pipeline. But just because there are no literature references doesn't mean a compound is not commercially available for research purposes. He says you "don't have to go that crazy to leave the paved roads behind," as there are many structures that haven't been explored yet.

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The Hill reports President Donald Trump issued an executive directing federal agencies to cut the number of board and advisory committees they have.

The New York Times reports that researchers are combining tools to more quickly develop crops to feed a growing population and cope with shifting climates.

Scientists in Canada are looking to the UK's plan to sequence children with rare conditions for inspiration, the National Post reports.

In PNAS this week: copy number changes arose during polar bear evolution, genomic and transcriptomic analysis of the Siberian hamster, and more.