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Not-So-Secret Drug Targets

Derek Lowe is used to sketching out compounds that don't yet exist, which he shares in this post at In the Pipeline. But just because there are no literature references doesn't mean a compound is not commercially available for research purposes. He says you "don't have to go that crazy to leave the paved roads behind," as there are many structures that haven't been explored yet. "Novelty is a key requirement for patentability, so seeing no references turn up around your interesting structure is good news from an IP standpoint."

The Scan

Gone, But Now Reconstructed SARS-CoV-2 Genomes

In a preprint, a researcher describes his recovery of viral sequences that had been removed from a common database.

Rare Heart Inflammation Warning

The Food and Drug Administration is adding a warning about links between a rare inflammatory heart condition and two SARS-CoV-2 vaccines, Reuters reports.

Sandwich Sampling

The New York Times sent tuna sandwiches for PCR analysis.

Nature Papers Describe Gut Viruses, New Format for Storing Quantitative Genomic Data, More

In Nature this week: catalog of DNA viruses of the human gut microbiome, new dense depth data dump format to store quantitative genomic data, and more.