Derek Lowe is used to sketching out compounds that don't yet exist, which he shares in this post at In the Pipeline. But just because there are no literature references doesn't mean a compound is not commercially available for research purposes. He says you "don't have to go that crazy to leave the paved roads behind," as there are many structures that haven't been explored yet. "Novelty is a key requirement for patentability, so seeing no references turn up around your interesting structure is good news from an IP standpoint."
Not-So-Secret Drug Targets
Jun 27, 2008