In a Guardian opinion piece published last week, plant geneticist Jonathan Latham spoke of "the failure of the genome." Latham said the human genome hasn't yielded the wealth of information on heritability and disease that was anticipated, and that "the failure to find meaningful inherited genetic predispositions is likely to become the most profound crisis that science has faced." But at Genomes Unzipped, Vincent Plagnol, Luke Jostins, and Daniel MacArthur are