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Not Convinced

In the Financial Times, a Glasgow general practitioner writes that the theory of personalized medicine is "nice" but that she doesn't "buy it." The GP, Margaret McCartney, says that "most genetic information does not give us clear-cut answers" as genes don't work in isolation from environment and that there is a lack of treatment, personalized or not, for many diseases. "My worry is that the use of genetic risk assessments to direct treatment will produce more dilemmas rather than less," McCartney writes. "Many of these conundrums will rest on our ability to assess and judge our risk of disease — and our abilities to prevent it."

The Scan

Ancient Greek Army Ancestry Highlights Mercenary Role in Historical Migrations

By profiling genomic patterns in 5th century samples from in and around Himera, researchers saw diverse ancestry in Greek army representatives in the region, as they report in PNAS.

Estonian Biobank Team Digs into Results Return Strategies, Experiences

Researchers in the European Journal of Human Genetics outline a procedure developed for individual return of results for the population biobank, along with participant experiences conveyed in survey data.

Rare Recessive Disease Insights Found in Individual Genomes

Researchers predict in Genome Medicine cross-population deletions and autosomal recessive disease impacts by analyzing recurrent nonallelic homologous recombination-related deletions.

Genetic Tests Lead to Potential Prognostic Variants in Dutch Children With Dilated Cardiomyopathy

Researchers in Circulation: Genomic and Precision Medicine found that the presence of pathogenic or likely pathogenic variants was linked to increased risk of death and poorer outcomes in children with pediatric dilated cardiomyopathy.