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Not Like This

Virginia's attorney general, Ken Cuccinelli, is a climate change-denying Tea Party favorite, says Bad Astronomy's Phil Plait, and for the past few years has been going after Michael Mann, a professor at Penn State. Cuccinelli is trying to prove that Mann's work is somehow fraudulent and is using his power of the subpoena to interfere with Mann's work, Plait adds. As bad as Cuccinelli's tactics are, however, Plait argues that two Virginia legislators who are trying to remove his ability to issue subpoenas are going about trying to protect legitimate scientists the wrong way. "As we may loathe some of the tactics being used to suppress science, if they're being done in a legal manner then we must find ways within the system to fight them, and not try to undermine the system itself to achieve that goal," he says.

The Scan

Drug Response Variants May Be Distinct in Somatic, Germline Samples

Based on variants from across 21 drug response genes, researchers in The Pharmacogenomics Journal suspect that tumor-only DNA sequences may miss drug response clues found in the germline.

Breast Cancer Risk Gene Candidates Found by Multi-Ancestry Low-Frequency Variant Analysis

Researchers narrowed in on new and known risk gene candidates with variant profiles for almost 83,500 individuals with breast cancer and 59,199 unaffected controls in Genome Medicine.

Health-Related Quality of Life Gets Boost After Microbiome-Based Treatment for Recurrent C. Diff

A secondary analysis of Phase 3 clinical trial data in JAMA Network Open suggests an investigational oral microbiome-based drug may lead to enhanced quality of life measures.

Study Follows Consequences of Early Confirmatory Trials for Accelerated Approval Indications

Time to traditional approval or withdrawal was shorter when confirmatory trials started prior to accelerated approval, though overall regulatory outcomes remained similar, a JAMA study finds.