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Norvatis and Roche to UK: We Might Quit You

In the Pipeline's Derek Lowe says Novartis and Roche are employing some "hardball negotiating" in their fight with the UK government over drug pricing and clinical trial regulations. Last week, the Guardian reported that the two companies threatened to pull their research and development departments out of the UK, a move that could put as many as 5,000 people out of work. Lowe asks who benefits from this move. The news was made public through a leak, so if it came from the companies, it could be a tactic to pressure the government even more. On the other hand, if the leak came from Britain's National Health Service, the purpose could be to make the companies look bad. Either way, he says, "I think it's unlikely that this would be followed through — but neither is it completely impossible, either, which is what makes it a reasonably effective move."

The Scan

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.

Rett Syndrome Mouse Model Study Points to RNA Editing Possibilities

Investigators targeted MECP2 in mutant mouse models of Rett syndrome, showing in PNAS that they could restore its expression and dial down symptoms.

Investigators Find Shared, Distinct Genetic Contributors to Childhood Hodgkin Lymphoma

An association study in JAMA Network Open uncovers risk variants within and beyond the human leukocyte antigen locus.

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.