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Nobel Laureate 'Bumped Into' Ubiquitin Discovery

The Scientist profiles Aaron Chiechanover, who shared the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation ― a determination he made as part of his PhD thesis. “We didn’t set out to identify ubiquitin. We didn’t know anything about ubiquitin or its function,” Ciechanover tellsThe Scientist. “We were studying intracellular proteolysis and we bumped into it.”

The Scan

Genetic Risk Factors for Hypertension Can Help Identify Those at Risk for Cardiovascular Disease

Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.

Circulating Tumor DNA Linked to Post-Treatment Relapse in Breast Cancer

Post-treatment detection of circulating tumor DNA may identify breast cancer patients who are more likely to relapse, a new JCO Precision Oncology study finds.

Genetics Influence Level of Depression Tied to Trauma Exposure, Study Finds

Researchers examine the interplay of trauma, genetics, and major depressive disorder in JAMA Psychiatry.

UCLA Team Reports Cost-Effective Liquid Biopsy Approach for Cancer Detection

The researchers report in Nature Communications that their liquid biopsy approach has high specificity in detecting all- and early-stage cancers.