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No One Really Knows How It Works

In the Science Times, Nicholas Wade delves into the importance of the epigenome in aging, disease, and regenerative medicine and how it is affected by the environment. He gives a good background of what's known so far about the epigenome -- something that would give your parents some understanding of what you've been talking about -- and then gets into recent work by Shinya Yamanaka and how ChIP-seq maps can help researchers determine just what's been going on in the epigenome.

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The Scan

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.

Study Reveals Potential Sex-Specific Role for Noncoding RNA in Depression

A long, noncoding RNA called FEDORA appears to be a sex-specific regulator of major depressive disorder, affecting more women, researchers report in Science Advances.

New mRNA Vaccines Offer Hope for Fighting Malaria

A George Washington University-led team has developed mRNA vaccines for malaria that appear to provide protection in mice, as they report in NPJ Vaccines.

Unique Germline Variants Found Among Black Prostate Cancer Patients

Through an exome sequencing study appearing in JCO Precision Oncology, researchers have found unique pathogenic or likely pathogenic variants within a cohort of Black prostate cancer patients.