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In Next-Gen Sequencing, Making Those Short Reads Useful

In today's PLoS ONE, researchers led by Andreas Sundquist describe a method called Short Read Assembly Protocol that they say will lead to inexpensive de novo sequencing of mammalian genomes. Using reads from next-gen sequencing technologies, this method uses a hierarchical sequencing strategy to produce a clone map and contigs so scientists can make more use of those short reads. The researchers, who include Mostafa Ronaghi and Pavel Pevzner, validated their protocol on portions of the human genome.

The Scan

Fertility Fraud Found

Consumer genetic testing has uncovered cases of fertility fraud that are leading to lawsuits, according to USA Today.

Ties Between Vigorous Exercise, ALS in Genetically At-Risk People

Regular strenuous exercise could contribute to motor neuron disease development among those already at genetic risk, Sky News reports.

Test Warning

The Guardian writes that the US regulators have warned against using a rapid COVID-19 test that is a key part of mass testing in the UK.

Science Papers Examine Feedback Mechanism Affecting Xist, Continuous Health Monitoring for Precision Medicine

In Science this week: analysis of cis confinement of the X-inactive specific transcript, and more.