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In Next-Gen Sequencing, Making Those Short Reads Useful

In today's PLoS ONE, researchers led by Andreas Sundquist describe a method called Short Read Assembly Protocol that they say will lead to inexpensive de novo sequencing of mammalian genomes. Using reads from next-gen sequencing technologies, this method uses a hierarchical sequencing strategy to produce a clone map and contigs so scientists can make more use of those short reads. The researchers, who include Mostafa Ronaghi and Pavel Pevzner, validated their protocol on portions of the human genome.

The Scan

Alzheimer's Risk Gene Among Women

CNN reports that researchers have found that variants in MGMT contribute to Alzheimer's disease risk among women but not men.

Still Hanging Around

The Guardian writes that persistent pockets of SARS-CoV-2 in the body could contribute to long COVID.

Through a Little Spit

Enteric viruses like norovirus may also be transmitted through saliva, not just the fecal-oral route, according to New Scientist.

Nature Papers Present Method to Detect Full Transcriptome, Viruses Infecting Asgard Archaea, More

In Nature this week: VASA-seq approach to detect full transcriptome, analysis of viruses infecting Asgard archaea, and more.