Next-gen Challenges

Back in the early days of next-gen sequencing, when the Solexa brand was still around, some serious challenges faced the field, MassGenomics' Dan Koboldt writes. Bioinformatics algorithms for capillary-based sequencing didn't scale, reads were shorter and error-prone, tools were expensive and hard to access, and few people had any experience with NGS.

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Researchers hope to tease out the signature effects that different carcinogens leave on the genome to determine their contributions to disease, Mosaic reports.

The Wall Street Journal looks into the cost of new gene therapies.

An Imperial College London-led team reports that it was able to use a gene drive to control a population of lab mosquitos.

In PNAS this week: genomic effects of silver fox domestication, limited effect of mitochondrial mutations on aging in fruit flies, and more.