Next-gen Challenges

Back in the early days of next-gen sequencing, when the Solexa brand was still around, some serious challenges faced the field, MassGenomics' Dan Koboldt writes. Bioinformatics algorithms for capillary-based sequencing didn't scale, reads were shorter and error-prone, tools were expensive and hard to access, and few people had any experience with NGS.

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Gene drives might run into biological resistance, the Economist reports.

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