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A New Standard

The US House of Representative passed a bill yesterday to reform the country's patent system, reports ScienceInsider. The bill would change the standard used to grant patents from the current "first to invent" standard to a "first to file" standard, which is more common in the rest of the world. The Senate passed a similar bill back in March, and the two versions need to be reconciled before being given to President Barack Obama, who the Chronicle of Higher Education notes, has indicated support for the legislation. The Chronicle adds that "university representatives have been divided on the plan, with some arguing that a first-to-file standard would put unwelcome pressure on their scientists to publish more quickly, and others saying that experiences overseas suggest such fears are unwarranted."

The Scan

Drug Response Variants May Be Distinct in Somatic, Germline Samples

Based on variants across 21 drug response genes, researchers in The Pharmacogenomics Journal suspect that tumor-only DNA sequences may miss drug response clues found in the germline.

Breast Cancer Risk Gene Candidates Found by Multi-Ancestry Low-Frequency Variant Analysis

Researchers narrowed in on new and known risk gene candidates with variant profiles for almost 83,500 individuals with breast cancer and 59,199 unaffected controls in Genome Medicine.

Health-Related Quality of Life Gets Boost After Microbiome-Based Treatment for Recurrent C. Diff

A secondary analysis of Phase 3 clinical trial data in JAMA Network Open suggests an investigational oral microbiome-based drug may lead to enhanced quality of life measures.

Study Follows Consequences of Early Confirmatory Trials for Accelerated Approval Indications

Time to traditional approval or withdrawal was shorter when confirmatory trials started prior to accelerated approval, though overall regulatory outcomes remained similar, a JAMA study finds.