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New Program for New Science

The National Science Foundation has launched a new program for researchers with unusual ideas, through which it will fund new types of research, reports ScienceInsider's Jeffrey Mervis. The program — Creative Research Awards for Transformative Interdisciplinary Ventures, or CREATIV — offers grants of up to $1 million over five years, and allows researchers to skip the normal peer-review process required to get funding, Mervis says. This new "streamlined" approach means that proposals won't be judged by external review panels, but only by NSF program managers, he adds. And funding decisions for this program will be made within two to three months. NSF Director Subra Suresh says the agency is looking for "unusually innovative, unconventional, high-risk, and interdisciplinary proposals."

The Scan

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.

TB Resistance Insights Gleaned From Genome Sequence, Antimicrobial Response Assays

Researchers in PLOS Biology explore M. tuberculosis resistance with a combination of sequencing and assays looking at the minimum inhibitory concentrations of 13 drugs.

Mendelian Disease Genes Prioritized Using Tissue-Specific Expression Clues

Mendelian gene candidates could be flagged for further functional analyses based on tissue-specific transcriptome and proteome profiles, a new Journal of Human Genetics paper says.

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.