In a primer, Edward Marcotte from the University of Texas walks readers through the basics of shotgun proteomics. After describing how to break up proteins into smaller pieces and how to run spectra through different databases, he says that "one area in which shotgun proteomics shows particular promise is the large-scale identification of post-translational modifications of proteins."

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The US Food and Drug Administration has approved Alnylam's RNAi-based therapy Onpattro, according to Stat News.

Harvard Medical School's Seth Cassel and Cigall Kadoch argue in a Baltimore Sun op-ed that the recent TAILORx trial shows the potential of genomic-based medicine.

Researchers in the UK are working on using gene drives to control malaria-carrying mosquitoes, the Telegraph reports.

In PLOS this week: genetic architecture mediating gene expression, metabolomic patterns in multiple myeloma, and more.