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New in Nature Biotechnology

In a primer, Edward Marcotte from the University of Texas walks readers through the basics of shotgun proteomics. After describing how to break up proteins into smaller pieces and how to run spectra through different databases, he says that "one area in which shotgun proteomics shows particular promise is the large-scale identification of post-translational modifications of proteins."

Two papers discuss ways to limit off-target cleavage by zinc finger nucleases, a promising technique for use in gene therapy. Both Jeffrey Miller and his colleagues at Sangamo and Michal Szczepek's group report that they engineered the FokI cleavage and dimerization domain of zinc finger nucleases to prefer heterodimer formation over homodimerization.

The Scan

NFTs for Genome Sharing

Nature News writes that non-fungible tokens could be a way for people to profit from sharing genomic data.

Wastewater Warning System

Time magazine writes that cities and college campuses are monitoring sewage for SARS-CoV-2, an approach officials hope lasts beyond COVID-19.

Networks to Boost Surveillance

Scientific American writes that new organizations and networks aim to improve the ability of developing countries to conduct SARS-CoV-2 genomic surveillance.

Genome Biology Papers on Gastric Cancer Epimutations, BUTTERFLY, GUNC Tool

In Genome Biology this week: recurrent epigenetic mutations in gastric cancer, correction tool for unique molecular identifier-based assays, and more.