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In a primer, Edward Marcotte from the University of Texas walks readers through the basics of shotgun proteomics. After describing how to break up proteins into smaller pieces and how to run spectra through different databases, he says that "one area in which shotgun proteomics shows particular promise is the large-scale identification of post-translational modifications of proteins."

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The US Department of Justice has proposed a rule change to enable DNA to be collected from migrants, the Associated Press reports.

Bernard Fisher, a surgeon who changed how breast cancer is treated, has died at 101, the New York Times reports.

Washington Post columnist writes that she is skeptical about DNA-based diets.

In PNAS this week: recurrent inactivation of DEPDC5 in gastrointestinal stromal tumors, taxonomic reliability of GenBank sequences, and more.