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New Head for CPRIT

Margaret Kripke is to be the new head of Cancer Prevention and Research Institute of Texas, reports the Nature News Blog. Kripke, who formerly served as the executive vice president and chief academic officer of the University of Texas' MD Anderson Cancer Center, will replace Al Gilman. Gilman resigned earlier this year, citing issues with the institute's peer-review process.

The Nature News Blog notes that Kripke "who will take up her new role in January, will immediately face the task of rebuilding the institute's reputation within the research community."

An unnamed MD Anderson physician tells the blog that "if there is a person who can clean up CPRIT, it's Margaret Kripke."

The Scan

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.

SpliceVault Portal Provides Look at RNA Splicing Changes Linked to Genetic Variants

The portal, described in Nature Genetics, houses variant-related messenger RNA splicing insights drawn from RNA sequencing data in nearly 335,700 samples — a set known as the 300K-RNA resource.

Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study

Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages.

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.