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The Nature Round-Up

In this News and Views article ($), Norman Sharpless and Ronald DePinho discuss bringing the tumor-suppressor gene p53 back to life. They tie together two Nature articles by lead authors Andrea Ventura and Wen Zue, and one by Carla Martins from Cell’s December issue. Since the pathway to tumor suppression is not damaged when p53 is turned off in cancerous cells, these papers conclude that restoring p53 leads to tumor regression and could be a cancer therapy.

A few pages later, Remco Sprangers and Lewis Kay report how they used NMR to study the 20S core particle of the proteasome. From this work, they gleaned a little bit more about how this large protein complex disposes of damaged and misfolded proteins.

The Scan

Tens of Millions Saved

The Associated Press writes that vaccines against COVID-19 saved an estimated 20 million lives in their first year.

Supersized Bacterium

NPR reports that researchers have found and characterized a bacterium that is visible to the naked eye.

Also Subvariants

Moderna says its bivalent SARS-CoV-2 vaccine leads to a strong immune response against Omicron subvariants, the Wall Street Journal reports.

Science Papers Present Gene-Edited Mouse Models of Liver Cancer, Hürthle Cell Carcinoma Analysis

In Science this week: a collection of mouse models of primary liver cancer, and more.