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The Nature Round-Up

In this News and Views article ($), Norman Sharpless and Ronald DePinho discuss bringing the tumor-suppressor gene p53 back to life. They tie together two Nature articles by lead authors Andrea Ventura and Wen Zue, and one by Carla Martins from Cell’s December issue. Since the pathway to tumor suppression is not damaged when p53 is turned off in cancerous cells, these papers conclude that restoring p53 leads to tumor regression and could be a cancer therapy.

A few pages later, Remco Sprangers and Lewis Kay report how they used NMR to study the 20S core particle of the proteasome. From this work, they gleaned a little bit more about how this large protein complex disposes of damaged and misfolded proteins.

The Scan

Missed Early Cases

A retrospective analysis of blood samples suggests early SARS-CoV-2 infections may have been missed in the US, the New York Times reports.

Limited Journal Editor Diversity

A survey finds low diversity among scientific and medical journal editors, according to The Scientist.

How Much of a Threat?

Science writes that need for a provision aimed at shoring up genomic data security within a new US bill is being questioned.

PNAS Papers on Historic Helicobacter Spread, Brain Development, C. difficile RNAs

In PNAS this week: Helicobacter genetic diversity gives insight into human migrations, gene expression patterns of brain development, and more.