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The Nanopore Race

The Kavli Institute of Nanoscience's Grégory Schneider and his colleagues are trying out using graphene for nanopore DNA sequencing, reports the Physics arXiv Blog. The researchers used an electron beam to make holes of various diameters in graphene sheets one atom thick. They then measured the current flowing across the sheet when the hole was empty and when a stand of DNA occupied the hole. "Sure enough, in these proof of principle experiments, the difference allowed them to determine when a strand of DNA was present or when two or more strands were stuck in the nanopore," according to the arXiv blog, which also notes that the team is in "a cutthroat race to produce the first nanopore translocation sequencer. They're up against teams from Harvard, Oxford and elsewhere who are all vying to master this trick and who have a few years' head start."

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.