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More Losses

Layoffs are hitting Sanofi-Aventis and possibly Astra-Zeneca and Eli Lilly, says Derek Lowe at In the Pipeline. He says that Astra-Zeneca's cuts may be "follow-through from their earlier nonspecific announcements - it looks as if they're finally going to start getting down to some details" and that at Lilly, some chemistry positions may be lost. Ed Silverman at Pharmalot adds that the Sanofi-Aventis cuts are coming in "dribs and drabs" and recently have included 70 people in medical affairs at its Bridgewater, NJ offices.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.