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The Money of Sequencing

There has been an increasing number of cases in which people have been helped medically by knowing their genome, and Forbes' Matthew Herper adds that "these pioneers have followed a path we're all likely to trod down — and one that the business world has not even begun to figure out how to monetize." Herper goes on to say that while the price of DNA sequencing is falling quickly — he mentions the price war between Illumina and Life Tech as well as the influx of new approaches from PacBio, Complete Genomics, and others as driving that decline — it's uncertain if sequencing will be the commodity or the interpretation of those sequences. "Researchers are building a road we'll all walk on. At some point, somebody has to figure out where to put the tolls," he says.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.