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Money, Mouths, and All That

ScienceInsider looks at the 2011 NIH budget to determine whether Francis Collins is favoring big science over single-investigator grants. Collins is emphasizing his five themes — high-throughput technologies, translational science, health care reform, global health, and reinvigorating biomedical research — and those areas have received large increases in the budget proposal. However, in 2011 NIH will fund 199 fewer research project grants will be funded. The Federation of American Societies for Experimental Biology's Howard Garrison says that change isn't due to policy, but a two percent increase in grant size. "Overall, the number of RPGs is rising, and the amount of money for them—$17.1 billion in 2011—is going up 3.2%, in step with NIH's overall budget," ScienceInsider says.

The Scan

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.

Team Presents Cattle Genotype-Tissue Expression Atlas

Using RNA sequences representing thousands of cattle samples, researchers looked at relationships between cattle genotype and tissue expression in Nature Genetics.

Researchers Map Recombination in Khoe-San Population

With whole-genome sequences for dozens of individuals from the Nama population, researchers saw in Genome Biology fine-scale recombination patterns that clustered outside of other populations.

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.