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A Mixed Bag

Times are still difficult for many biotechs, but Ed Silverman writes at Pharmalot that the situation is actually a bit variable. Drawing on a report from consulting firm BDO, Silverman notes that biotech firms spent slightly more on R&D in 2011 than in 2010, though he adds that while large biotechs reported about 33 percent increase in revenue, smaller biotechs have not seen such large gains, reporting 12 percent decline in revenue.

"With revenues growing, it is no surprise that biotech firms are again investing substantial dollars in research and development," says BDO's Ryan Starkes in a statement. "However, broader economic challenges persist. Smaller companies are struggling to generate returns on their past investments, and continue to target innovative medicines in hopes of greater revenues down the road."

The Scan

Suicidal Ideation-Linked Loci Identified Using Million Veteran Program Data

Researchers in PLOS Genetics identify risk variants within and across ancestry groups with a genome-wide association study involving veterans with or without a history of suicidal ideation.

Algorithm Teases Out Genetic Ancestry in Individuals at Biobank Scale

Researchers develop an algorithm known as Rye to tease apart ancestry fractions in admixed individuals at a biobank-scale, applying it to 488,221 UK Biobank participants in Nucleic Acids Research.

Multi-Ancestry Analysis Highlights Comparable Common Variants at Complex Trait-Linked Loci

Researchers in Nature Genetics examine common variants implicated in more than three dozen conditions, estimating genetic effect similarities across ancestry tracts in admixed individuals.

Sick Newborns Selected for WGS With Automated Pipeline

Researchers successfully prioritized infants with potential Mendelian conditions for whole-genome sequencing or rapid whole-genome sequencing, as they report in Genome Medicine.