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Mind the Gaps

Joy Yang, a post-bac fellow at the US National Human Genome Research Institute, dubs Daniel MacArthur et al.'s "systematic survey of loss-of-function variants in human protein-coding genes" — recently published in Science — the "genome advance of the month." Yang says the results of MacArthur and his colleague's study, which drew on 1,000 Genomes Project data, were somewhat surprising.

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Bloomberg reports AstraZeneca may conduct another study of its candidate SARS-CoV-2 vaccine after dosing error.

Moderna is applying for an Emergency Use Authorization for its coronavirus vaccine, according to the New York Times.

The National Health Service is to conduct a trial of Grail's blood-based screening test for cancer.

In PLOS this week: somatic mutation patterns of glioblastomas among Lebanese patients, phenome-wide study using UK Biobank data, and more.