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Migration of the Monarch

Researchers from University of Massachusetts Medical School and Genome Project Solutions present on the draft genome of the monarch butterfly, Danaus plexippus, in Cell this week. Monarch butterflies migrate each fall from North America to central Mexico, and the researchers focus their analyses on gene families in the 273 Mb genome likely to be involved in seasonal migration. "With this genome sequence in hand, we now have an overwhelming number of opportunities to understand the genetic and molecular basis of long-distance migration," says UMass's Steven Reppert in a statement.

Our sister publication GenomeWeb Daily News has more on the monarch butterfly genome here.

The Scan

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.

SpliceVault Portal Provides Look at RNA Splicing Changes Linked to Genetic Variants

The portal, described in Nature Genetics, houses variant-related messenger RNA splicing insights drawn from RNA sequencing data in nearly 335,700 samples — a set known as the 300K-RNA resource.

Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study

Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages.

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.