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Microbes All Around

In the New York Times, Carl Zimmer writes about the human microbiome and its role in disease. He begins the piece by describing a fecal transplant that treated a patient's Clostridium difficile infection in her gut. In addition, Zimmer describes the microbiome project being led by the University of Washington in St. Louis' George Weinstock that is studying all the bacteria found in humans as well as the recent findings that babies delivered by Caesarean section are colonized mostly by bacteria found on adult human skin and that mice without a microbiome can't make IL-10, which helps reduce inflammation. "Surrounding us and infusing us is this cloud of microbes," says WashU's Jeffrey Gordon.

The Scan

Study Finds Few FDA Post-Market Regulatory Actions Backed by Research, Public Assessments

A Yale University-led team examines in The BMJ safety signals from the US FDA Adverse Event Reporting System and whether they led to regulatory action.

Duke University Team Develops Programmable RNA Tool for Cell Editing

Researchers have developed an RNA-based editing tool that can target specific cells, as they describe in Nature.

Novel Gene Editing Approach for Treating Cystic Fibrosis

Researchers in Science Advances report on their development of a non-nuclease-based gene editing approach they hope to apply to treat cystic fibrosis.

Study Tracks Responses in Patients Pursuing Polygenic Risk Score Profiling

Using interviews, researchers in the European Journal of Human Genetics qualitatively assess individuals' motivations for, and experiences with, direct-to-consumer polygenic risk score testing.