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Of Mice and Women

Nature News reports that the lack of female research participants — from basic research in animals to clinical trials with human patients — has significant consequences, such as, "for example, when drug candidates fail to get regulatory approval because they don’t work in women in late-stage clinical trials." Nature notes that researchers tend to prefer the use of male lab animals to limit the potential for the variability of female animals’ estrous cycles, and that the ratio of male- to female-only studies in basic neuroscience is 5.5 to 1. According to Nature, investigators in attendance at the Workshop on Sex Differences and Implications for Translational Neuroscience Research, suggested that journals require authors to report the sex of the animals used in their research and that funding agencies should ask grant applicants to disclose the sex of the animals they propose to study, "and justify their decision whenever they chose only male animals."

The Scan

Fertility Fraud Found

Consumer genetic testing has uncovered cases of fertility fraud that are leading to lawsuits, according to USA Today.

Ties Between Vigorous Exercise, ALS in Genetically At-Risk People

Regular strenuous exercise could contribute to motor neuron disease development among those already at genetic risk, Sky News reports.

Test Warning

The Guardian writes that the US regulators have warned against using a rapid COVID-19 test that is a key part of mass testing in the UK.

Science Papers Examine Feedback Mechanism Affecting Xist, Continuous Health Monitoring for Precision Medicine

In Science this week: analysis of cis confinement of the X-inactive specific transcript, and more.