Of Mice and MicroRNA

A new paper out of Harvard screened embryonic stem cells and found a factor called Lin-28 that inhibits Drosha, which usually cleaves the ends of miRNAs. Lin-28, though, only prevents the processing of miRNAs belonging to the let7 family. The authors suggest that Lin-28 then may prevent miRNA-mediated differentiation in stem cells and some cancers.

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