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Of Mice and Methylation

Eric Lander's group has a new paper in the advance online section of Nature in which they describe how they used high-throughput reduced representation bisulphite sequencing coupled with single-molecule-based sequencing to generate DNA methylation maps from mouse primary tissues, including embryonic stem cells, embryonic-stem-cell-derived, and primary neural cells. They found that methylation patterns correlate with histone methylation patterns rather than with the genome sequence. They also say that CpG methylation is dynamic and that weak CpG islands associated with certain development genes undergo hypermethylation in vitro in a pattern they say is similar to what occurs in tumors.

The Scan

Another Resignation

According to the Wall Street Journal, a third advisory panel member has resigned following the US Food and Drug Administration's approval of an Alzheimer's disease drug.

Novavax Finds Its Vaccine Effective

Reuters reports Novavax's SARS-CoV-2 vaccine is more than 90 percent effective in preventing COVID-19.

Can't Be Used

The US Food and Drug Administration says millions of vaccine doses made at an embattled manufacturing facility cannot be used, the New York Times reports.

PLOS Papers on Frozen Shoulder GWAS, Epstein-Barr Effects on Immune Cell Epigenetics, More

In PLOS this week: genome-wide association study of frozen shoulder, epigenetic patterns of Epstein-Barr-infected B lymphocyte cells, and more.