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Of Mice and Methylation

Eric Lander's group has a new paper in the advance online section of Nature in which they describe how they used high-throughput reduced representation bisulphite sequencing coupled with single-molecule-based sequencing to generate DNA methylation maps from mouse primary tissues, including embryonic stem cells, embryonic-stem-cell-derived, and primary neural cells. They found that methylation patterns correlate with histone methylation patterns rather than with the genome sequence. They also say that CpG methylation is dynamic and that weak CpG islands associated with certain development genes undergo hypermethylation in vitro in a pattern they say is similar to what occurs in tumors.

The Scan

Alzheimer's Risk Gene Among Women

CNN reports that researchers have found that variants in MGMT contribute to Alzheimer's disease risk among women but not men.

Still Hanging Around

The Guardian writes that persistent pockets of SARS-CoV-2 in the body could contribute to long COVID.

Through a Little Spit

Enteric viruses like norovirus may also be transmitted through saliva, not just the fecal-oral route, according to New Scientist.

Nature Papers Present Method to Detect Full Transcriptome, Viruses Infecting Asgard Archaea, More

In Nature this week: VASA-seq approach to detect full transcriptome, analysis of viruses infecting Asgard archaea, and more.