Researchers at the Mitchell Cancer Institute compared expression stabilities of miRNA from fresh frozen and formalin-fixed, paraffin-embedded samples, providing first-time evidence that FFPE samples might be used to study miRNA expression in cancer and other diseases. Using high-throughput, locked nucleic acid-based miRNA arrays and miRNA qRT-PCR analysis, they found that the two showed good correlation and that among 40 colorectal cancer FFPE samples, there was no significant difference of miRNA expression. Their published research can be found in RNA.
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