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Measuring miRNA Isn't So Hard Anymore...

Researchers at the Mitchell Cancer Institute compared expression stabilities of miRNA from fresh frozen and formalin-fixed, paraffin-embedded samples, providing first-time evidence that FFPE samples might be used to study miRNA expression in cancer and other diseases. Using high-throughput, locked nucleic acid-based miRNA arrays and miRNA qRT-PCR analysis, they found that the two showed good correlation and that among 40 colorectal cancer FFPE samples, there was no significant difference of miRNA expression. Their published research can be found in RNA.

 

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.