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Measuring Microbe Metabolism with Metagenomics

In PNAS, Mark Gerstein and his colleagues describe a new method to quantify microbial metabolic pathways in metagenomics samples. Using data from the Global Ocean Survey, the researchers developed a multivariate approach to associate metabolic pathway usage to differences in the environment. They identified pathways used in energy conversion, amino acid metabolism, cofactor synthesis, and more. "Our study provides an analytical framework for uncovering ways, in which microbes adapt to (and perhaps even) how they change their environment," the authors write.

The Scan

Study Finds Few FDA Post-Market Regulatory Actions Backed by Research, Public Assessments

A Yale University-led team examines in The BMJ safety signals from the US FDA Adverse Event Reporting System and whether they led to regulatory action.

Duke University Team Develops Programmable RNA Tool for Cell Editing

Researchers have developed an RNA-based editing tool that can target specific cells, as they describe in Nature.

Novel Gene Editing Approach for Treating Cystic Fibrosis

Researchers in Science Advances report on their development of a non-nuclease-based gene editing approach they hope to apply to treat cystic fibrosis.

Study Tracks Responses in Patients Pursuing Polygenic Risk Score Profiling

Using interviews, researchers in the European Journal of Human Genetics qualitatively assess individuals' motivations for, and experiences with, direct-to-consumer polygenic risk score testing.