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Maybe There's Just Some Bad Juju

At In the Pipeline, Derek Lowe blogs about cursed compounds -- classes of compounds that seem so tantalizingly promising but that almost never can be turned into a drug. He cites the protease inhibitors trifluoromethyl ketones as an example. "Although several of these have gone into the clinic over the years, I can't think of one that's [made] it all the way to the market," Lowe writes. He also notes that at least one cursed compound example -- hydroxamic acid -- has been made into a drug, but that it's targeted at cancer, where desperation for treatment has led to less rigorous standards.

 

The Scan

Genetic Risk Factors for Hypertension Can Help Identify Those at Risk for Cardiovascular Disease

Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.

Circulating Tumor DNA Linked to Post-Treatment Relapse in Breast Cancer

Post-treatment detection of circulating tumor DNA may identify breast cancer patients who are more likely to relapse, a new JCO Precision Oncology study finds.

Genetics Influence Level of Depression Tied to Trauma Exposure, Study Finds

Researchers examine the interplay of trauma, genetics, and major depressive disorder in JAMA Psychiatry.

UCLA Team Reports Cost-Effective Liquid Biopsy Approach for Cancer Detection

The researchers report in Nature Communications that their liquid biopsy approach has high specificity in detecting all- and early-stage cancers.