Skip to main content
Premium Trial:

Request an Annual Quote

Maybe There's Just Some Bad Juju

At In the Pipeline, Derek Lowe blogs about cursed compounds -- classes of compounds that seem so tantalizingly promising but that almost never can be turned into a drug. He cites the protease inhibitors trifluoromethyl ketones as an example. "Although several of these have gone into the clinic over the years, I can't think of one that's [made] it all the way to the market," Lowe writes. He also notes that at least one cursed compound example -- hydroxamic acid -- has been made into a drug, but that it's targeted at cancer, where desperation for treatment has led to less rigorous standards.