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Maybe Not All the Miracles, But Surely Some of Them?

The New York Times reports on a paper coming out in Nature Medicine that seems to explain why some patients respond to beta blockers while others don't (we'll give you a hint: genetic variation). The gene linked to this variance is carried by up to 40 percent of black people but just 2 percent of white people, which helps explain why the drugs have appeared to respond or not respond along racial lines. The story quotes author Stephen Liggett (that's Mr. Claire Fraser to the GTO community) as saying, "Conceptually, this is quite a surprise."

The idea has clear application in a pharmacogenomic setting. For more on that topic, check out NYT's interview with Arno Motulsky, who's referred to as the "father of pharmacogenomics." He says there will have to be more research before PGx can really be put into practice, and that "what we know about the genome today is not enough for all the miracles many expect from this field."

 

The Scan

Gone, But Now Reconstructed SARS-CoV-2 Genomes

In a preprint, a researcher describes his recovery of viral sequences that had been removed from a common database.

Rare Heart Inflammation Warning

The Food and Drug Administration is adding a warning about links between a rare inflammatory heart condition and two SARS-CoV-2 vaccines, Reuters reports.

Sandwich Sampling

The New York Times sent tuna sandwiches for PCR analysis.

Nature Papers Describe Gut Viruses, New Format for Storing Quantitative Genomic Data, More

In Nature this week: catalog of DNA viruses of the human gut microbiome, new dense depth data dump format to store quantitative genomic data, and more.