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Mass Spec on the Microbial Outbreak Scene

Researchers at the Brisbane, Australia-based diagnostic lab Mater Pathology report in a Journal of Clinical Microbiology paper appearing online in advance this week on their MALDI-TOF mass spectrometry-based investigation of Vancomycin-resistant Enterococcus faecium. The Mater Pathology team reports having applied MALDI-TOF MS to quickly and accurately identify vanB positive E. faecium VRE from susceptible isolates, and to ascertain the relatedness of isolates contributing to an outbreak. "Internal validation of the optimal model generated produced a sensitivity of 92.4 percent and specificity of 85.2 percent," the authors write, adding that "prospective validation results, following incorporation into routine laboratory workflow, demonstrated a greater sensitivity and specificity at 96.7 percent and 98.1 percent respectively."

The Scan

Ancient Greek Army Ancestry Highlights Mercenary Role in Historical Migrations

By profiling genomic patterns in 5th century samples from in and around Himera, researchers saw diverse ancestry in Greek army representatives in the region, as they report in PNAS.

Estonian Biobank Team Digs into Results Return Strategies, Experiences

Researchers in the European Journal of Human Genetics outline a procedure developed for individual return of results for the population biobank, along with participant experiences conveyed in survey data.

Rare Recessive Disease Insights Found in Individual Genomes

Researchers predict in Genome Medicine cross-population deletions and autosomal recessive disease impacts by analyzing recurrent nonallelic homologous recombination-related deletions.

Genetic Tests Lead to Potential Prognostic Variants in Dutch Children With Dilated Cardiomyopathy

Researchers in Circulation: Genomic and Precision Medicine found that the presence of pathogenic or likely pathogenic variants was linked to increased risk of death and poorer outcomes in children with pediatric dilated cardiomyopathy.