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Mass Spec Mania

This week's issue of PNAS focuses on mass spectrometry and "attempts to illustrate the breadth and uniqueness of applications of molecular MS to a variety of scientific fields with current examples." Matthias Mann and Neil Kelleher write about how the latest generation of mass spectrometers has helped proteomics come of age and how precision proteomics is now possible. One paper reports on using DESI-MS imaging to see the distribution of clozapine, an antipsychotic drug, and its metabolite in brain, lung, kidney, and testis samples. In another, Vanderbilt researchers used imaging MS to look at Aβ isoform distributions in Alzheimer's plaque samples, mouse brain protein maps, and protein distribution in breast carcinoma. Other papers cover petroleomics, detecting extraterrestrial aromatic molecules, nanocalorimetry, among other topics.

The Scan

Fertility Fraud Found

Consumer genetic testing has uncovered cases of fertility fraud that are leading to lawsuits, according to USA Today.

Ties Between Vigorous Exercise, ALS in Genetically At-Risk People

Regular strenuous exercise could contribute to motor neuron disease development among those already at genetic risk, Sky News reports.

Test Warning

The Guardian writes that the US regulators have warned against using a rapid COVID-19 test that is a key part of mass testing in the UK.

Science Papers Examine Feedback Mechanism Affecting Xist, Continuous Health Monitoring for Precision Medicine

In Science this week: analysis of cis confinement of the X-inactive specific transcript, and more.