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Maq Still Leading the Way

Dan Koboldt of the MassGenomics blog will be presenting a poster at this year's Marco Island sequencing meeting evaluating short read aligners. He's compiled a partial list of aligners, which include first and foremost, Maq. "It’s safe to say that we decided to gamble on Maq over a year ago, and so far, the bet has paid off," he writes. Other options include Novoalign, Bowtie, cross_match, RMAP (which he hears the developers have stopped working on), and SOAP ("probably a tool to watch"). While his evaluations seem to beg for aligners that can handle gaps and paired end reads, his main criteria are speed, compatibility with in-house platforms, and "aligners that can beat Maq -- in performance, features, or sensitivity -- and that's not easy to do. Maq is fast and does quality-based alignment, single or paired-end, assembly, SNP calling… there's a reason why the rest of the industry seems to be conforming to it," he writes.

The Scan

Billions for Antivirals

The US is putting $3.2 billion toward a program to develop antivirals to treat COVID-19 in its early stages, the Wall Street Journal reports.

NFT of the Web

Tim Berners-Lee, who developed the World Wide Web, is auctioning its original source code as a non-fungible token, Reuters reports.

23andMe on the Nasdaq

23andMe's shares rose more than 20 percent following its merger with a special purpose acquisition company, as GenomeWeb has reported.

Science Papers Present GWAS of Brain Structure, System for Controlled Gene Transfer

In Science this week: genome-wide association study ties variants to white matter stricture in the brain, and more.