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Mapping Bias

A Bioinformatics paper from Jonathan Pritchard's lab at the University of Chicago looked into how SNP variation affects read-mapping reliability, particularly in relation to allele-specific expression. "We have shown here that differential mapping of SNP alleles can greatly affect inferences that rely on quantifying DNA or RNA with next-generation sequencing data.

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A survey by Nature finds that most researchers want scientific meetings to continue virtually or with a virtual component, even after the pandemic ends.

Bloomberg reports that the B.1.351 SARS-CoV-2 viral variant could prompt the formulation of better vaccines.

Certain blood proteins may be able to distinguish COVID-19 patients who will become critically ill from those who will not, the Atlanta Journal-Constitution reports.

In Genome Biology this week: algorithm to assess regulatory features, approach to integrate multiple single-cell RNA-seq datasets, and more.