Skip to main content
Premium Trial:

Request an Annual Quote

Mapping Bias

A Bioinformatics paper from Jonathan Pritchard's lab at the University of Chicago looked into how SNP variation affects read-mapping reliability, particularly in relation to allele-specific expression. "We have shown here that differential mapping of SNP alleles can greatly affect inferences that rely on quantifying DNA or RNA with next-generation sequencing data. This may be especially problematic in studies that aim to detect allele-specific differences in gene expression, transcription factor binding or other related applications," the authors write.

Dan Koboldt at MassGenomics weighs in on the study. "Your reaction might be to shrug, since Illumina/Solexa now routinely generates 76-bp and 100-bp reads," he says, adding that there are "a number of reasons why this might not address the bias issue" including that the lengths of alignment seeds have not changed and that many groups are still rely on shorter reads.

The Scan

Billions for Antivirals

The US is putting $3.2 billion toward a program to develop antivirals to treat COVID-19 in its early stages, the Wall Street Journal reports.

NFT of the Web

Tim Berners-Lee, who developed the World Wide Web, is auctioning its original source code as a non-fungible token, Reuters reports.

23andMe on the Nasdaq

23andMe's shares rose more than 20 percent following its merger with a special purpose acquisition company, as GenomeWeb has reported.

Science Papers Present GWAS of Brain Structure, System for Controlled Gene Transfer

In Science this week: genome-wide association study ties variants to white matter stricture in the brain, and more.