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Mapping Bias

A Bioinformatics paper from Jonathan Pritchard's lab at the University of Chicago looked into how SNP variation affects read-mapping reliability, particularly in relation to allele-specific expression. "We have shown here that differential mapping of SNP alleles can greatly affect inferences that rely on quantifying DNA or RNA with next-generation sequencing data.

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Russia says its candidate SARS-CoV-2 vaccine has a very high efficacy rate in an initial analysis of clinical trial data, according to the Financial Times.

Wired reports on a microbial analysis of sketches drawn by Leonardo DaVinci.

A new survey explores coronavirus vaccine hesitancy among Black and Latino individuals, the Washington Post reports.

In Nucleic Acids Research this week: the Aging Atlas database, a database of human metagenome-related metadata, and more.