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Making Plans

The US National Institutes of Health recently received funds to create the National Center for Advancing Translational Sciences. The center's acting director, Thomas Insel, who is also in charge of the National Institute of Mental Health, sat down with ScienceInsider's Jocelyn Kaiser to talk about some of NIH's plans for NCATS, and how the new center will work with industry to improve R&D.

Insel tells her that NCATS will have an intramural program, but that the center will also try to break down the wall that separates intramural and extramural research. "So we're looking at NCATS as a place to raise questions about the relationship of intramural to extramural and how we can get them to cross talk and provide a much more dynamic kind of relationship than what we've had up until now," Insel says.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.