The life sciences field needs better, more flexible, upgradeable, and scientist-friendly big data management tools. John Boyle, soon to be senior director of bioinformatics at Kymab, writes in Nature.

Boyle says that many data management projects focused on the helping life sciences investigators manage and analyze large data sets have failed because these systems are hard to create, harder to use, and have used a one-size-fits-all approach.

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The UK's Nuffield Council on Bioethics says genetically modifying human embryos could be morally permissible, according to the Guardian.

A new Nature Biotechnology paper reports that CRISPR-Cas9 gene editing can lead to large deletions or complex rearrangements that could be pathogenic.

The Wall Street Journal likens a prototype developed by Synthetic Genomics to a "biological fax machine."

In PNAS this week: strategy for reactivating Rett syndrome-linked MECP2, small molecules able to suppress Staphylococcus aureus virulence, and more.