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Making the Call

MassGenomic's Dan Koboldt discusses his latest Bioinformatics paper. In it, he presents VarScan, which is a program he developed to call SNPs and indels from next-gen sequencing data. The two main challenges to making accurate calls are telling the difference between real variants and false positives in short reads and holding the volume of data. "VarScan detects sequence variants, combines them by position and type, and then computes the read counts, average base quality, and number of strands supporting each allele," Kolbodt says. He later adds that most SNPs called by VarScan were in dbSNP, supported by Illumina/Solexa calls, or both.

The Scan

Another Resignation

According to the Wall Street Journal, a third advisory panel member has resigned following the US Food and Drug Administration's approval of an Alzheimer's disease drug.

Novavax Finds Its Vaccine Effective

Reuters reports Novavax's SARS-CoV-2 vaccine is more than 90 percent effective in preventing COVID-19.

Can't Be Used

The US Food and Drug Administration says millions of vaccine doses made at an embattled manufacturing facility cannot be used, the New York Times reports.

PLOS Papers on Frozen Shoulder GWAS, Epstein-Barr Effects on Immune Cell Epigenetics, More

In PLOS this week: genome-wide association study of frozen shoulder, epigenetic patterns of Epstein-Barr-infected B lymphocyte cells, and more.