Making the Call

MassGenomic's Dan Koboldt discusses his latest Bioinformatics paper. In it, he presents VarScan, which is a program he developed to call SNPs and indels from next-gen sequencing data. The two main challenges to making accurate calls are telling the difference between real variants and false positives in short reads and holding the volume of data.

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The Seattle Times writes that pharmacogenomics testing can help choose medications that may work best for people with depression.

Researchers report that deleting one gene from butterflies affects their wing coloration patterns, according to the Washington Post.

In PNAS this week: genome sequencing of weevil symbionts, retinoid X receptor deletion in lung cancer metastasis, and more.

Sequencing could help combat foodborne illnesses, according to a blog post by Food and Drug Administration officials.