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Making the Call

MassGenomic's Dan Koboldt discusses his latest Bioinformatics paper. In it, he presents VarScan, which is a program he developed to call SNPs and indels from next-gen sequencing data. The two main challenges to making accurate calls are telling the difference between real variants and false positives in short reads and holding the volume of data.

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The US Food and Drug Administration is to announce stricter standards for emergency authorizations of SARS-CoV-2 vaccines, reports the Washington Post.

Bloomberg reports the budget of Operation Warp Speed is actually $18 billion, higher than the number typically cited.

The Associated Press reports Johnson & Johnson is starting a late-stage clinical trial of its candidate SARS-CoV-2 vaccine.

In Genome Research this week: genomic analysis reveals role of super-spreaders in SARS-CoV-2, epigenetic drivers of cancer, and more.