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A study in today's Cell, shows how the loss of E3 ubiquitin ligase can cause Angelman syndrome, a genetic disorder that causes developmental problems in children. More than 10 years ago, researchers found that Angelman was caused by a single gene mutation, but could not explain the mechanism. Harvard's Michael Greenberg and his colleagues found that the loss of Ube3A interferes with the brain's ability to use environmental experiences to fine-tune neuronal circuits.

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Russia says its candidate SARS-CoV-2 vaccine has a very high efficacy rate in an initial analysis of clinical trial data, according to the Financial Times.

Wired reports on a microbial analysis of sketches drawn by Leonardo DaVinci.

A new survey explores coronavirus vaccine hesitancy among Black and Latino individuals, the Washington Post reports.

In Nucleic Acids Research this week: the Aging Atlas database, a database of human metagenome-related metadata, and more.