Researchers at Tsinghua University in Beijing have looked at how miRNAs recognize their target mRNAs. In a study published today in PLoS ONE, they examined the effect of the loop region in miRNA/miRNA recognizing element (MRE) duplexes, and found that the central loop is an important factor affecting the efficiency of gene regulation. From their studies, they created a predictive score that would rate the loop's effectiveness according to both its size and location, and found that by using these, their MRE predictions improved.
The Loop Might Hold the Answer
Mar 05, 2008