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The Loop Might Hold the Answer

Mar 05, 2008

Researchers at Tsinghua University in Beijing have looked at how miRNAs recognize their target mRNAs. In a study published today in PLoS ONE, they examined the effect of the loop region in miRNA/miRNA recognizing element (MRE) duplexes, and found that the central loop is an important factor affecting the efficiency of gene regulation. From their studies, they created a predictive score that would rate the loop's effectiveness according to both its size and location, and found that by using these, their MRE predictions improved.

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