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Looking at Diversity

Researchers are hoping to capture some of the diversity seen in Latin Americans through the new Slim Initiative for Genomic Health between the Broad Institute and Mexico City's Carlos Slim Health Institute, says MIT's Technology Review. That project is still in the planning stages — though it will include gene sequencing and microarray-based studies — but INMEGEN published a Mexican version of the HapMap last year. "We can clearly see different components in the admixture pattern in the Mexican population," says Gerardo Jimenez-Sanchez, former director of INMEGEN. "We can also observe that the Mexican population is a range of admixture from those individuals who are very European to those who are very indigenous." Jimenez-Sanchez adds that "if personalized medicine is going to become a global phenomenon, then scientists need to understand the genomes of all the world's population."

The Scan

UCLA Team Reports Cost-Effective Liquid Biopsy Approach for Cancer Detection

The researchers report in Nature Communications that their liquid biopsy approach has high specificity in detecting all- and early-stage cancers.

Machine Learning Improves Diagnostic Accuracy of Breast Cancer MRI, Study Shows

Combining machine learning with radiologists' interpretations further increased the diagnostic accuracy of MRIs for breast cancer, a Science Translational Medicine paper finds.

Genome Damage in Neurons Triggers Alzheimer's-Linked Inflammation

Neurons harboring increased DNA double-strand breaks activate microglia to lead to neuroinflammation like that seen in Alzheimer's disease, a new Science Advances study finds.

Long COVID-19 Susceptibility Clues Contained in Blood Plasma Proteome

A longitudinal study in eBioMedicine found weeks-long blood plasma proteome shifts after SARS-CoV-2 infection, along with proteomic signatures that appeared to coincide with long Covid risk.