The Long-Read Game

Long-reads sequencing is once again at the forefront, writes Michael Eisenstein at Nature Biotechnology. A few years ago, Pacific Biosciences made a splash at the 2010 Advances in Genome Biology and Technology meeting with its RS machine, which it said at the time could produce sequences as long as 20,000 bases. However, as Eisenstein notes, the approach was limited by a low throughput and high error rate.

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