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A Long Reach

Transcription factor KLF14 can work as a master trans regulator of adipose gene expression, says a report in Nature Genetics from a number of consortiums. For this study, the researchers looked at more than 20,000 genes in subcutaneous fat biopsies obtained from 800 female twins from the UK, and found an association between KLF14 and the expression levels of other distantly located genes. The findings were then confirmed in an Icelandic population. "Expression levels of genes regulated by this trans-eQTL are highly correlated with concurrently measured metabolic traits, and a subset of the trans-regulated genes harbor variants directly associated with metabolic phenotypes," the authors write. CNN's The Chart blog adds, "The findings mean that the KLF14 gene could become the possible target for treatment efforts to fight against diseases related to metabolism and obesity."

The Scan

Study Links Evolution of Longevity, Social Organization in Mammals

With the help of comparative phylogenetics and transcriptomics, researchers in Nature Communications see ties between lifespan and social organization in mammals.

Tumor Microenvironment Immune Score Provides Immunotherapy Response, Prognostic Insights

Using multiple in situ analyses and RNA sequence data, researchers in eBioMedicine have developed a score associated with immunotherapy response or survival.

CRISPR-Based Method for Finding Cancer-Associated Exosomal MicroRNAs in Blood

A team from China presents in ACS Sensors a liposome-mediated membrane fusion strategy for detecting miRNAs carried in exosomes in the blood with a CRISPR-mediated reporter system.

Drug Response Variants May Be Distinct in Somatic, Germline Samples

Based on variants from across 21 drug response genes, researchers in The Pharmacogenomics Journal suspect that tumor-only DNA sequences may miss drug response clues found in the germline.