A Long Reach

Transcription factor KLF14 can work as a master trans regulator of adipose gene expression, says a report in Nature Genetics from a number of consortiums. For this study, the researchers looked at more than 20,000 genes in subcutaneous fat biopsies obtained from 800 female twins from the UK, and found an association between KLF14 and the expression levels of other distantly located genes. The findings were then confirmed in an Icelandic population.

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