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The Little Things Add Up

On their own, many cryptic mutations may not amount to much, but together they can allow organisms to adapt quickly to new circumstances, says Ed Yong at Scientific American.

For example, he points to small, seemingly neutral mutations to neuraminidase in the influenza virus that, in conjunction with a H274Y mutation to that protein, allows the virus to evade the effects of Tamiflu.

"Both mutations looked innocuous individually, but together they made the virus more adaptable in the face of a challenge," Yong writes. "To put it another way, they made it better at evolving."

He adds that such mutations could play a role in a number of traits, from height to schizophrenia, where genes have been associated, but that also suffer from apparent levels of 'missing heritability.' "This is just wild speculation on my part, but it sounds reasonable to me," the University of Pennsylvania's Joshua Plotkin tells Yong.

The Scan

Renewed Gain-of-Function Worries

The New York Times writes that the pandemic is renewing concerns about gain-of-function research.

Who's Getting the Patents?

A trio of researchers has analyzed gender trends in biomedical patents issued between 1976 and 2010 in the US, New Scientist reports.

Other Uses

CBS Sunday Morning looks at how mRNA vaccine technology could be applied beyond SARS-CoV-2.

PLOS Papers Present Analysis of Cervicovaginal Microbiome, Glycosylation in Model Archaea, More

In PLOS this week: functional potential of the cervicovaginal microbiome, glycosylation patterns in model archaea, and more.