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Limit for Resurrecting Old Viruses

Except for a handful of vials in the US and Russia, the smallpox virus has been eradicated from the globe, writes Leonard Adleman, a professor of computer science and molecular biology at the University of Southern California, in a New York Times op-ed. But, he adds that the virus has found a second host — the computer.

In the 1990s, Adleman notes, a team including Craig Venter sequenced the virus' genome, and it's easily accessible to anyone who searches online for it. While Adleman says that a computer file can't kill you, it's becoming easier for labs to re-create viruses from just their genome sequence.

"Do we sit and wait for the day when someone releases resurrected smallpox on an unvaccinated world?" he asks. "I'm a scientist, not a policy expert. But would it be wise for us to consider limiting the distribution of the tools of this emerging technology?"

The Scan

Cancer Survival Linked to Mutational Burden in Pan-Cancer Analysis

A pan-cancer paper appearing in JCO Precision Oncology suggests tumor mutation patterns provide clues for predicting cancer survival that are independent of other prognostic factors.

Australian Survey Points to Public Support for Genetic Risk Disclosure in Relatives of At-Risk Individuals

A survey in the European Journal of Human Genetics suggests most adult Australians are in favor of finding out if a relative tests positive for a medically actionable genetic variant.

Study Links Evolution of Stony Coral Skeleton to Bicarbonate Transporter Gene

A PNAS paper focuses on a skeleton-related bicarbonate transporter gene introduced to stony coral ancestors by tandem duplication.

Hormone-Based Gene Therapy to Sterilize Domestic Cat

A new paper in Nature Communication suggests that gene therapy could be a safer alternative to spaying domestic cats.