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"Light" Smoking is No Refuge from Lung Cancer

The University of Cincinnati's Marshall Anderson and his colleagues in Genetic Epidemiology of Lung Cancer Consortium uncovered a risk locus on chromosome 6q that increases a person's risk of developing lung cancer even if that person is a light smoker. The study, which is published in Cancer Research, found that for family members born without this variant, the risk of developing lung cancer tracked very closely with level of smoking — smoke more, have a higher risk of lung cancer. But in family members born with this risk haplotype, even light smoking resulted in greatly increased risk for developing lung cancer, and increasing smoking only marginally increased the risk.

The Scan

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.

Team Presents Cattle Genotype-Tissue Expression Atlas

Using RNA sequences representing thousands of cattle samples, researchers looked at relationships between cattle genotype and tissue expression in Nature Genetics.

Researchers Map Recombination in Khoe-San Population

With whole-genome sequences for dozens of individuals from the Nama population, researchers saw in Genome Biology fine-scale recombination patterns that clustered outside of other populations.

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.