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Let's Hear It for the Gloom and Doom Department

The drama continues over Pfizer's deal for Wyeth. This Review & Outlook opinion piece from the Wall Street Journal doesn't mince words about the situation, starting off with this: "Emergency is too strong a word for Pfizer's $68 billion agreement to buy Wyeth, but not by much. The deal shows the afflictions that beset the larger American pharmaceutical industry, which ought to concern anyone who cares about U.S. medical innovation." And just in case you thought there might be good news down the line, the column goes on to warn about political stumbling blocks within FDA, and refers to Pfizer's CEO as "a lawyer who came to the drug giant from McDonald's in 2006 and has been laying off scientific staff all over the place."

The Scan

Study Finds Few FDA Post-Market Regulatory Actions Backed by Research, Public Assessments

A Yale University-led team examines in The BMJ safety signals from the US FDA Adverse Event Reporting System and whether they led to regulatory action.

Duke University Team Develops Programmable RNA Tool for Cell Editing

Researchers have developed an RNA-based editing tool that can target specific cells, as they describe in Nature.

Novel Gene Editing Approach for Treating Cystic Fibrosis

Researchers in Science Advances report on their development of a non-nuclease-based gene editing approach they hope to apply to treat cystic fibrosis.

Study Tracks Responses in Patients Pursuing Polygenic Risk Score Profiling

Using interviews, researchers in the European Journal of Human Genetics qualitatively assess individuals' motivations for, and experiences with, direct-to-consumer polygenic risk score testing.