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Let 'Em Loose

A guest post at Olivia Judson's On the Wild Side column from Stanford's Steven Quake discusses how science is funded in the US. After start-up packages run dry, professors must earn their own as well as their students' keep through grants. Quake says running a lab is very much like running a small business, but at the cost of riskier, creative ideas being denied funding and lost. He writes that it is time to re-think how science is funded and "let scientists off their leashes."

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.